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Related Experiment Video

Updated: Dec 16, 2025

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
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Challenges for Microelectronics in Non-Invasive Medical Diagnostics.

Marco Carminati1,2, Carlo Fiorini1,2

  • 1Politecnico di Milano, Dipartimento di Elettronica Informazione e Bioingegneria, 20133 Milano, Italy.

Sensors (Basel, Switzerland)
|July 3, 2020
PubMed
Summary

Microelectronics, including CMOS analog application-specific integrated circuits (ASICs), are crucial for advancing diagnostic technologies. Challenges remain in integrating these chips with microfluidic devices and multi-modal imaging systems for improved healthcare solutions.

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Area of Science:

  • Medical Electronics
  • Integrated Circuit Design
  • Diagnostic Technologies

Background:

  • Microelectronics are increasingly vital for diagnostics, though integration challenges persist.
  • Application-specific integrated circuits (ASICs) offer miniaturization and power efficiency in portable analytical devices.
  • Current research addresses the integration of CMOS chips with microfluidics and advances in multi-modal imaging systems.

Purpose of the Study:

  • To review recent advancements and identify technical challenges in microelectronic design for diagnostics.
  • To explore the integration of CMOS analog ASICs in micro-analytical devices and multi-modal imaging systems.
  • To discuss open issues in microfluidics integration and gamma camera development for scintigraphy and MRI.

Main Methods:

Keywords:
ASICsCMOS biosensorsSiPMgamma cameraslab-on-chipmulti-modal medical imagingnuclear electronicsradiation detector

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  • Review of current research in CMOS analog ASIC design for diagnostic applications.
  • Analysis of integration challenges between microelectronics, microfluidics, and bio-sensing.
  • Examination of microelectronic roles in gamma cameras for SPECT/MRI and portable analytical platforms.

Main Results:

  • CMOS ASICs are key for miniaturization and managing the noise/power trade-off in portable diagnostics.
  • Integration of CMOS chips with microfluidics presents significant technological hurdles.
  • Microelectronics enable faster, simplified SPECT imaging and hardware pre-processing for multi-modal systems.

Conclusions:

  • Microelectronics, particularly CMOS ASICs, are pivotal for the future of diagnostic technologies.
  • Addressing integration challenges in microfluidics and multi-modal imaging is essential for technological consolidation.
  • Future directions include enhanced microelectronic solutions for portable diagnostics and advanced imaging applications.