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Related Experiment Video

Updated: Dec 16, 2025

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
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Proinflammatory and Anti-inflammatory Genes in Stroke Pathogenesis.

Mengmeng Jiang1,2,3, Penglin Yin1,2,3, Xiaodan Bai1,2,3

  • 1Medical Experiment Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Current Pharmaceutical Design
|July 3, 2020
PubMed
Summary

Stroke triggers brain inflammation involving immune cells and mediators. This review explores the role of inflammatory genes in stroke pathogenesis and current drug interventions targeting inflammation.

Keywords:
Strokebrain injuryclinical trialsinflammatory reactionneutrophilspro-inflammatory/anti-inflammatory genes

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Area of Science:

  • Neuroscience
  • Immunology
  • Pathology

Background:

  • Ischemic injury initiates acute and chronic brain inflammation.
  • Key players include resident microglia, macrophages, neutrophils, and lymphocytes.
  • These cells modulate inflammation via mediator release, but gene regulation remains unclear.

Purpose of the Study:

  • To investigate the inflammatory process following stroke.
  • To elucidate the role of specific pro-inflammatory and anti-inflammatory genes in stroke pathogenesis.
  • To review current clinical trials targeting inflammatory mechanisms for stroke intervention.

Main Methods:

  • Literature review of inflammatory processes in ischemic stroke.
  • Analysis of the role of pro-inflammatory and anti-inflammatory genes.
  • Summary of clinical trials focused on anti-inflammatory drug targets.

Main Results:

  • Stroke involves complex immune cell activation and mediator production.
  • Distinct temporal roles for pro-inflammatory and anti-inflammatory mediators exist.
  • Understanding gene regulation is crucial for targeted therapies.

Conclusions:

  • Inflammation is central to stroke pathophysiology.
  • Targeting specific inflammatory genes offers therapeutic potential.
  • Further research into gene regulation is needed to advance stroke treatment.