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Clinical application of target temperature management in children with acute encephalopathy-A practical review

Jainn-Jim Lin1, Shao-Hsuan Hsia2, Ming-Chou Chiang3

  • 1Division of Pediatric Critical Care and Pediatric Neurocritical Care Center, Chang Gung Children's Hospital at Linkou, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Pediatric Neurology, Chang Gung Children's Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Biomedical Journal
|July 3, 2020
PubMed

Insights

Target temperature management (TTM) shows promise for treating acute encephalopathy in children, a condition causing brain dysfunction and potential long-term neurological issues. This review explores TTM

Area of Science:

  • Pediatric Neurology
  • Neurocritical Care
  • Neuroprotection

Background:

  • Acute encephalopathy is a critical condition in children, leading to brain dysfunction, mortality, and significant neurological sequelae in up to 30% of cases.
  • Current therapeutic strategies for acute encephalopathy lack established efficacy in ameliorating patient outcomes.
  • Target temperature management (TTM), a neuroprotective strategy, is recognized for its effectiveness in various brain injuries.

Purpose of the Study:

  • To review the practical applications of Target Temperature Management (TTM) for pediatric acute encephalopathies.
  • To discuss the potential of TTM as an intervention for improving outcomes in children with acute brain dysfunction.

Main Methods:

  • Review of current literature on Target Temperature Management (TTM).
  • Analysis of TTM's neuroprotective mechanisms and clinical applications.
  • Discussion of TTM's relevance in pediatric neurocritical care.

Main Results:

  • TTM is established in treating adult cardiac arrest and perinatal asphyxia.
  • Evidence suggests TTM's efficacy in other acute encephalopathies like status epilepticus, encephalitis, and traumatic brain injury.
  • TTM is considered a cornerstone neuroprotective strategy with potential benefits for various pediatric acute encephalopathies.

Conclusions:

  • Target temperature management (TTM) is a promising intervention for acute encephalopathies in children.
  • Further exploration of TTM's practical aspects is warranted for pediatric neurocritical care.
  • TTM offers potential neuroprotection and improved outcomes for children suffering from acute brain dysfunction.

Keywords:
Acute encephalopathyCardiac arrestChildrenHypoxic-ischemic encephalopathyTarget temperature managementTherapeutic hypothermia

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