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Isolated pulmonary vasculitis associated with nilotinib use: A case report
Nicolette T Morris1, Mihaela B Taylor1, Melkon Hacobian2
1Division of Rheumatology, University of California, Los Angeles, David Geffen School of Medicine, California, USA.
Tyrosine-kinase inhibitor therapy for chronic myeloid leukemia may cause vascular issues. A patient on nilotinib developed pulmonary artery and coronary artery stenosis, suggesting possible drug-induced vasculitis.
Area of Science:
- Cardiology
- Oncology
- Rheumatology
Background:
- Tyrosine-kinase inhibitors (TKIs) like nilotinib are used for chronic myeloid leukemia (CML).
- Previous studies have linked TKI therapy to vascular adverse events, including peripheral arterial disease, coronary artery disease, and pulmonary hypertension.
- Vasculitis, inflammation of blood vessels, is a potential but less commonly reported complication.
Purpose of the Study:
- To report a case of isolated pulmonary artery vasculitis and coronary artery stenosis in a patient treated with nilotinib.
- To highlight the importance of considering drug-induced vasculitis in patients on long-term nilotinib therapy.
Main Methods:
- Case report of a CML patient on nilotinib therapy.
- Clinical presentation, diagnostic workup, and management of the patient's vascular complications.
Main Results:
- The patient developed isolated pulmonary artery vasculitis leading to left pulmonary artery stenosis.
- The patient also developed left coronary artery stenosis.
- These vascular events occurred during nilotinib treatment.
Conclusions:
- Nilotinib therapy, while effective for CML, may be associated with drug-induced vasculitis.
- Clinicians should be vigilant for vasculitis in patients receiving chronic nilotinib treatment, in addition to monitoring for other cardiovascular events.
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