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Novel copper-based and pH-sensitive nanomedicine for enhanced chemodynamic therapy
Li Wang1, Zhicheng Zhang1, Yawen Ding1
1State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & School of Life Sciences, Nanjing University, Nanjing 210093, P. R. China. huyiqiao@nju.edu.cn yuannju@nju.edu.cn.
Abstract:
We utilized albumin as a reducing agent to establish novel copper-based and pH-sensitive nanocarrier CuNPs with abundant Cu+, which can encapsulate histone deacetylase (HDAC) inhibitor vorinostat to form uniform and stable nanomedicine V-CuNPs for synergistic chromatin remodelling and chemodynamic therapy.

