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A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.6K

Hepatitis c virus and chronic kidney disease

Muhammad Umair Khan1, Mohamed Ibrahim Mahmoud1, Adeel A Butt2,3

  • 1Department of Medicine, Division of Gastroenterology, Hamad Medical Corporation , Doha, Qatar.

Expert Review of Gastroenterology & Hepatology
|July 3, 2020
PubMed

Insights

Direct acting antiviral agents (DAAs) effectively treat Hepatitis C virus (HCV) infection, achieving high viral eradication rates. These treatments are safe and well-tolerated in patients with chronic kidney disease (CKD) and those who have undergone renal transplantation.

Area of Science:

  • Nephrology
  • Hepatology
  • Virology

Background:

  • Hepatitis C virus (HCV) infection is linked to increased chronic kidney disease (CKD) incidence, progression, and mortality in CKD and renal transplant patients.
  • Direct acting antiviral agents (DAAs) have transformed HCV treatment, achieving high viral eradication rates.
  • DAAs demonstrate excellent safety and tolerability in CKD and renal transplant populations.

Purpose of the Study:

  • To review the association between HCV and CKD incidence, progression, and patient outcomes.
  • To discuss HCV treatment options for patients with CKD, renal transplants, and HCV-associated glomerular disease.

Main Methods:

  • Literature review focusing on HCV, CKD, renal transplantation, and DAA therapies.
  • Analysis of treatment outcomes, safety, and tolerability of DAAs in specific patient cohorts.

Main Results:

  • DAAs achieve 90-100% viral eradication in treated patients, including those with advanced CKD and on dialysis.
  • DAAs are safe and effective in renal transplant recipients.
  • HCV-infected grafts can be utilized with successful post-transplant viral eradication.

Conclusions:

  • DAAs represent a revolutionary advancement for treating HCV in patients with advanced CKD and end-stage renal disease.
  • The efficacy, safety, and tolerability of DAAs facilitate HCV treatment in both dialysis and renal transplant patients.
  • DAA therapy enables successful management of HCV in renal transplant recipients, including those receiving HCV-viremic grafts.
Abstract

Keywords:
CKDDAAHCVSofosbuvirhemodialysisrenal transplant

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