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Lentinan-functionalized selenium nanosystems with high permeability infiltrate solid tumors by enhancing
Fan Yang1, Jiarun Huang1, Hongxing Liu2
1Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China and Department of Chemistry, Jinan University, Guangzhou 510632, P. R. China. tchentf@jnu.edu.cn.
Nanoscale
|July 3, 2020
Summary
Researchers developed novel selenium nanoparticles (SeNPs) decorated with lentinan (LET) and Tw-80. These LET-Tw-SeNPs show enhanced tumor penetration and inhibit cancer cell growth, offering a promising strategy for solid tumor treatment.
Area of Science:
- Nanomedicine and Drug Delivery
- Oncology
- Materials Science
Background:
- Delivering nanomedicines into solid tumors is challenging for chemotherapy.
- Effective tumor penetration is crucial for successful cancer treatment.
Purpose of the Study:
- To synthesize stable and efficient selenium nanoparticles (SeNPs) for solid tumor penetration and treatment.
- To evaluate the transcellular transport and therapeutic efficacy of the developed nanosystem.
Main Methods:
- Synthesis of selenium nanoparticles (SeNPs) using Tw-80 and lentinan (LET).
- In vitro studies on HepG2 cells and tumor spheroids to assess cellular uptake and penetration.
- Evaluation of anti-cancer effects, including proliferation inhibition, migration, cell cycle arrest, and reactive oxygen species (ROS) generation.
- Pharmacokinetic analysis to determine blood half-life.
Main Results:
- The developed LET-Tw-SeNPs demonstrated ideal size and transcellular transport capability.
- Significant cellular uptake by HepG2 cells via receptor-mediated endocytosis was observed.
- The nanosystem showed enhanced penetration into HepG2 tumor spheroids.
- LET-Tw-SeNPs inhibited HepG2 cell proliferation and migration by inducing cell cycle arrest.
- Internalized nanoparticles led to ROS overproduction and mitochondrial rupture.
- Pharmacokinetic studies revealed a long half-life of LET-Tw-SeNPs in the blood.
Conclusions:
- This study presents an innovative nanosystem (LET-Tw-SeNPs) for efficient in-depth tumor drug delivery.
- The developed nanosystem exhibits high permeability and low blood clearance, beneficial for solid tumor treatment.
- This strategy holds potential for future clinical applications in treating solid tumors.
