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[Restoration of immune status by interleukin 2?]
1Zentralinstitut für Molekularbiologie, Akademie der Wissenschaften der DDR.
Beyond a donor age (a) of 22 years, the DNA incision ability in human peripheral lymphocytes was found to decrease according to 1/a2.5. Other lymphocyte functions linked to the differentiation program may follow this age-dependency. First results show that interleukin-2 is able to compensate, at least partly, the age-dependent deficiency of immune response.
Beyond a donor age (a) of 22 years, the DNA incision ability in human peripheral lymphocytes was found to decrease according to 1/a2.5. Other lymphocyte functions linked to the differentiation program may follow this age-dependency. First results show that interleukin-2 is able to compensate, at least partly, the age-dependent deficiency of immune response.