Giant Fibroepithelial Polyps: Why do they Grow Excessively?

Area of Science:

• Dermatology
• Pathology
• Oncology

Background:

• Fibroepithelial polyps (FEPs), also known as skin tags, are common benign skin tumors typically found in skin folds.
• While usually small, FEPs can exceptionally reach giant sizes, with etiology and growth factors like obesity and insulin resistance under investigation.
• Recent literature suggests lymphedema and chronic inflammation may also contribute to FEP growth.

Observation:

• A unique case of a 14x6 cm giant fibroepithelial polyp is presented in a 21-year-old patient.
• The polyp was located on the midline of the anterior chest wall, an unusual site for such large FEPs.
• This presentation is novel, representing the first reported instance of a giant FEP in this specific anatomical location.

Findings:

• The case contributes to the understanding of FEPs, particularly giant variants.
• It underscores the potential for FEPs to grow to significant dimensions in atypical locations.
• The report includes a review of current literature on FEP diagnosis, treatment, and causative factors.

Implications:

• This case expands the known clinical spectrum and anatomical distribution of giant fibroepithelial polyps.
• It may prompt further investigation into the specific mechanisms driving excessive FEP growth in unusual locations.
• Understanding these factors is crucial for accurate diagnosis and effective management of FEPs.