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Updated: Dec 16, 2025

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
Published on: April 28, 2020
[Acute hemolysis crisis revealed a Wilson disease]
Guillaume Feugray1, Jennifer Guillerme2, François Fraissinet2
1Service d'hématologie biologique, Institut de biologie clinique, CHU-Hôpitaux de Rouen, France.
Abstract:
Wilson disease is a rare inherited disorder of copper metabolism that affects liver and brain due to copper tissue accumulation. The mechanism involved is based on mutations of the ATP7B gene. Children have predominant hepatic manifestations while adult are more often diagnosed by neurological and psychiatric symptoms. However, others features are tubulopathy, articular disorders and hemolytic anemia. We report the diagnostic of Wilson disease in a 14 years old girl and her sibling after investigation of hemolytic anemia, hepatic insufficiency, and hypophosphatemia.
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