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The Masquelet technique: Current concepts, animal models, and perspectives.

Céline Klein1,2, Michael Monet2, Vincent Barbier1,2

  • 1Department of Pediatric Orthopedic Surgery, Amiens University Medical Center, Jules Verne University of Picardie, Amiens, France.

Journal of Tissue Engineering and Regenerative Medicine
|July 5, 2020
PubMed
Summary

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The Masquelet technique uses a spacer to create an induced membrane for bone reconstruction. This review examines animal models of this technique to understand the underlying biological mechanisms of bone regeneration.

Area of Science:

  • Orthopedic surgery
  • Tissue engineering
  • Regenerative medicine

Background:

  • Critical-sized bone defects pose significant challenges in orthopedic surgery.
  • The Masquelet technique, a two-step approach, utilizes a poly(methylmethacrylate) spacer to induce a membrane for bone reconstruction.
  • This technique offers advantages over traditional methods like vascularized bone flaps or Ilizarov's technique.

Purpose of the Study:

  • To review existing animal models for Masquelet technique-induced membrane formation.
  • To analyze the surgical procedures, defect sites, and histological/osteogenic properties of induced membranes in animal models.
  • To discuss the advantages and disadvantages of current animal models to aid future research into the biological mechanisms.

Main Methods:

Keywords:
Masquelet techniqueanimal modelsbone healingcritical-sized defectinduced membranetissue engineering

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  • Comprehensive literature review of animal models for Masquelet technique-induced membrane formation.
  • Analysis of studies focusing on defect site, surgical procedure, and induced membrane characteristics.
  • Comparative discussion of the strengths and weaknesses of various animal models.

    • Main Results:

    • The review encompasses various aspects of induced membrane formation in animal models.
    • Key findings highlight the heterogeneity in reported defect sites, surgical techniques, and histological/osteogenic evaluations.
    • The study identifies gaps in understanding the precise biological mechanisms driving membrane induction and subsequent bone regeneration.

    Conclusions:

    • Understanding the biological mechanisms of the Masquelet technique is crucial for optimizing bone reconstruction.
    • Further development and standardization of animal models are needed to facilitate mechanistic studies.
    • This review provides a foundation for future research aimed at elucidating the complex processes involved in induced membrane formation and bone regeneration.