Heart Failure in Adult Congenital Heart Disease

Luke J Burchill1, Melissa G Y Lee2, Vidang P Nguyen3

  • 1Department of Cardiology, The Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, VIC 3050, Australia; Department of Medicine, The University of Melbourne, Melbourne, Australia.

Cardiology Clinics
|July 6, 2020
PubMed

Insights

Heart failure is a growing concern for adults with congenital heart disease, presenting significant challenges in diagnosis and treatment. This review highlights the need for standardized classification and advanced management strategies for this complex patient group.

Area of Science:

  • Cardiology
  • Adult Congenital Heart Disease
  • Heart Failure

Background:

  • The population of adult congenital heart disease (ACHD) patients is increasing.
  • Heart failure (HF) is a major cause of morbidity and mortality in ACHD.
  • Current management of HF in ACHD faces significant challenges.

Purpose of the Study:

  • To review the challenges in determining the burden of HF in ACHD.
  • To discuss the management of HF in ACHD.
  • To highlight the need for a common language and advanced treatment strategies.

Main Methods:

  • Literature review focusing on HF in ACHD.
  • Analysis of challenges in classification, presentation, prognostication, and treatment.
  • Utilization of a case study to illustrate key concepts.

Main Results:

  • HF in ACHD is a complex and growing clinical problem.
  • Standardized classification and reporting of HF in ACHD are lacking.
  • Hemodynamic evaluation and advanced HF treatments require further investigation in ACHD.

Conclusions:

  • Addressing HF in ACHD requires a common language for classification and reporting.
  • Improved understanding of clinical presentation and prognostication is crucial.
  • Advanced therapies and hemodynamic evaluation are essential for optimal management of HF in ACHD.

Related Concept Videos

Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
596
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
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Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
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Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
251
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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