Related Experiment Video
Updated: Dec 16, 2025
08:05
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
14.6K
Systemic Capillary Leak Syndrome Secondary to Coronavirus Disease 2019
Robert Case1, Aliaksandr Ramaniuk1, Pamela Martin1
1University of Florida Health, Gainesville, FL.
Chest
|July 6, 2020
Summary
Systemic capillary leak syndrome (SCLS) is a rare disorder. This case report details the first instance of SCLS occurring alongside a COVID-19 infection, highlighting a new inflammatory complication.
Area of Science:
- Internal Medicine
- Infectious Diseases
- Critical Care Medicine
Background:
- Systemic capillary leak syndrome (SCLS) is a rare, life-threatening disorder.
- SCLS involves endothelial dysfunction and plasma extravasation, leading to shock and organ failure.
- Viral infections are a known potential trigger for SCLS.
Observation:
- A patient with acute coronavirus disease 2019 (COVID-19) presented with symptoms of SCLS, including hemoconcentration, shock, and hypoalbuminemia.
- The patient also developed severe complications, such as rhabdomyolysis and compartment syndrome in all four extremities, necessitating fasciotomies.
Findings:
- This case represents the first documented instance of SCLS occurring in conjunction with a COVID-19 infection.
- The clinical presentation underscores the potential for severe inflammatory responses triggered by SARS-CoV-2.
Implications:
- This case expands the known spectrum of inflammatory complications associated with COVID-19.
- It suggests that SCLS should be considered in the differential diagnosis of patients with severe COVID-19 presenting with shock and hemoconcentration.
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
379
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
379
01:21Acute Respiratory Failure-II
874
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
874
01:26Nephrotic Syndrome II : Assessment and Medical Management
125
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
125
01:29Pneumonia II: Pathophysiology
2.3K
The pathophysiology of pneumonia involves the following steps:
2.3K
01:21Acute Respiratory Failure-I
656
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
656
01:30Acute Respiratory Failure-III
614
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
614