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Endothelial function and aqueous humor flow rate in patients with Fuchs' dystrophy
S E Wilson1, W M Bourne, P C O'Brien
1Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905.
American Journal of Ophthalmology
|September 15, 1988
Summary
Fuchs
Area of Science:
- Ophthalmology
- Corneal Diseases
- Ocular Surface
Background:
- Fuchs' dystrophy is a progressive corneal disease.
- Corneal guttae are a hallmark of Fuchs' dystrophy.
- Endothelial dysfunction is implicated in disease progression.
Purpose of the Study:
- To assess endothelial permeability in Fuchs' dystrophy.
- To correlate corneal guttae severity with endothelial function.
- To investigate stromal edema in relation to endothelial permeability.
Main Methods:
- Two-dimensional scanning fluorophotometry was used.
- 50 subjects with Fuchs' dystrophy were studied.
- Subjects were grouped by cornea guttata severity and corneal thickness.
Main Results:
- No significant differences in endothelial permeability were found between groups.
- Corneal thickness was significantly increased in subjects with advanced cornea guttata.
- Stromal edema was present in subjects with advanced guttae.
Conclusions:
- Endothelial permeability is not significantly altered in early to moderate Fuchs' dystrophy.
- Advanced cornea guttata with stromal edema may indicate impaired endothelial pump function.
- Further research is needed to fully understand endothelial dysfunction in Fuchs' dystrophy.