Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Perspective on 3D Bioprinting in Tissue Regeneration.

Bio-design and manufacturing·2019

Same author

Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels.

Science advances·2019

Same author

Hierarchically Patterned Polydopamine-Containing Membranes for Periodontal Tissue Engineering.

ACS nano·2019

Same author

A Microfabricated Sandwiching Assay for Nanoliter and High-Throughput Biomarker Screening.

Small (Weinheim an der Bergstrasse, Germany)·2019

Same author

A simple layer-stacking technique to generate biomolecular and mechanical gradients in photocrosslinkable hydrogels.

Biofabrication·2019

Same author

Advancing Frontiers in Bone Bioprinting.

Advanced healthcare materials·2019

Same journal

Corrigendum to "Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide" [Biomaterials 42 (2015) 16442].

Biomaterials·2026

Same journal

An injectable Ce-MnCo LDH nanozyme gel with cascade catalytic activity for acute radiation proctitis in rats.

Biomaterials·2026

Same journal

Peptide coacervate-mediated siRNA delivery for dual PD-1/PD-L1 blockade to enhance colorectal cancer immunotherapy.

Biomaterials·2026

Same journal

A sonosensitizing hydrogel with tumour-confined stability for intrinsically targeted sonodynamic therapy.

Biomaterials·2026

Same journal

Multidimensional intestinal barrier repair strategies for alleviating inflammatory bowel disease and gut-liver axis-associated metabolic liver disease.

Biomaterials·2026

Same journal

A dual-twisted molecular strategy achieves dramatic quantum-yield enhancement in NIR-II AIEgen for high-performance bioimaging.

Biomaterials·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 16, 2025

Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research

Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research

Published on: May 24, 2024

Gut-on-a-chip: Current progress and future opportunities.

Nureddin Ashammakhi¹, Rohollah Nasiri², Natan Roberto de Barros³

¹Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, CA, USA; Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Department of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, CA, USA.

|July 6, 2020

Summary

This summary is machine-generated.

Organ-on-a-chip technology advances gut research by mimicking native tissues in vitro. These models offer a promising alternative to animal studies for drug development and personalized medicine.

Keywords:

Gut Microfluidics Microphysiological systems Organ-on-a-chip Tissue engineering

More Related Videos

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

Related Experiment Videos

Last Updated: Dec 16, 2025

Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research

Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research

Published on: May 24, 2024

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

Area of Science:

Biomedical Engineering
Gastroenterology
In Vitro Models

Background:

Organ-on-a-chip technology aims to replicate native tissue complexity in vitro.
Recent advancements focus on gut-on-a-chip models, with and without microbiota.
These models serve as alternatives to animal studies for physiological, pathological, and pharmacological research.

Purpose of the Study:

To highlight the progress and potential of gut-on-a-chip models.
To identify current limitations in representing gut endocrine and immunological functions.
To discuss challenges in constructing complex, multi-cellular gut models.

Main Methods:

Utilizing organ-on-a-chip platforms to create in vitro gut models.
Incorporating microbiota into gut-on-a-chip systems.
Comparing gut-on-a-chip models to traditional 2D cell cultures and animal models.

Main Results:

Gut-on-a-chip models show improved physiological relevance over 2D systems.
Endocrine and immunological functions remain underrepresented in current gut-on-a-chip models.
Constructing complex, interactive gut models presents ongoing challenges.

Conclusions:

Gut-on-a-chip models hold significant potential for advancing gut research.
These models can improve understanding of gut physiology, pathophysiology, and drug responses.
Future applications include drug development and personalized medical treatments.