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Human T cell specific proteinase (HuTSP) is encoded by the T cell and natural killer cell specific human Hanukah
U Fruth1, C Eckerskorn, F Lottspeich
1Max-Planck-Institut für Immunbiologie, Freiburg, FRG.
FEBS Letters
|September 12, 1988
Abstract:
HuTSP, a serine proteinase which is specifically associated with activated t lymphocytes, was purified to homogeneity and characterized. N-terminal amino acid sequencing revealed identity with a sequence predicted from the human Hanukah factor (HF) gene, which was isolated from a human T cell cDNA library. The dimeric structure of HuTSP, together with its extensive sequence homologies with the murine T cell specific proteinase, MTSP-1, suggests phylogenetic conservation of this serine proteinase family.