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Related Experiment Video

Updated: Dec 16, 2025

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

Integrated Microphysiological Systems: Transferable Organ Models and Recirculating Flow.

Kasper Renggli¹, Nassim Rousset¹, Christian Lohasz¹

¹ETH Zürich, Department of Biosystems Science and Engineering, Mattenstrasse 26, 4058, Basel, Switzerland.

Advanced Biosystems

|July 7, 2020

Summary

This summary is machine-generated.

Developing transferable in vitro organ models integrated into microphysiological systems (MPSs) enhances drug discovery. These models improve reproducibility and stability for better understanding of tissue and disease mechanisms.

Keywords:

3D microtissues biological barrier models in vitro organ models microfluidics microphysiological systems

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Last Updated: Dec 16, 2025

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Area of Science:

Biomedical Engineering
Drug Discovery
In Vitro Models

Background:

Accurate biological model systems are crucial for studying tissue and disease mechanisms.
Microphysiological systems (MPSs) utilize microfluidics for precise control of in vitro 3D organ models, mimicking in vivo environments.
Current models require improvements in stability and reproducibility for wider adoption.

Purpose of the Study:

To review transferable in vitro organ models and integrated MPSs.
To highlight the benefits of interchangeable organ models for quality control and on-demand assay development.
To discuss challenges and future directions for integrated MPSs with transferable organ models.

Main Methods:

Focus on transferable in vitro organ models and their integration into MPSs.
Discusses off-chip production and quality control of biological models.
Reviews technical and biological challenges in realizing integrated MPSs.

Main Results:

Transferable organ models allow for independent quality control before system assembly.
Integrated MPSs with transferable models enable interactions between different tissue types.
Off-chip production enhances system stability and reproducibility.

Conclusions:

Transferable in vitro organ models within integrated MPSs offer a promising approach for drug development and disease research.
Addressing technical and biological challenges is key for large-scale adoption.
This technology has the potential to significantly advance in vitro modeling capabilities.