Integrated Microphysiological Systems: Transferable Organ Models and Recirculating Flow

Area of Science:

• Biomedical Engineering
• Drug Discovery
• In Vitro Models

Background:

• Accurate biological model systems are crucial for studying tissue and disease mechanisms.
• Microphysiological systems (MPSs) utilize microfluidics for precise control of in vitro 3D organ models, mimicking in vivo environments.
• Current models require improvements in stability and reproducibility for wider adoption.

Purpose of the Study:

• To review transferable in vitro organ models and integrated MPSs.
• To highlight the benefits of interchangeable organ models for quality control and on-demand assay development.
• To discuss challenges and future directions for integrated MPSs with transferable organ models.

Main Methods:

• Focus on transferable in vitro organ models and their integration into MPSs.
• Discusses off-chip production and quality control of biological models.
• Reviews technical and biological challenges in realizing integrated MPSs.

Main Results:

• Transferable organ models allow for independent quality control before system assembly.
• Integrated MPSs with transferable models enable interactions between different tissue types.
• Off-chip production enhances system stability and reproducibility.

Conclusions:

• Transferable in vitro organ models within integrated MPSs offer a promising approach for drug development and disease research.
• Addressing technical and biological challenges is key for large-scale adoption.
• This technology has the potential to significantly advance in vitro modeling capabilities.