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Lack of hybridization between Yersinia enterocolitica and HLA-B27 DNA
A M Viitanen1, R Lahesmaa-Rantala, E Weiss
1Department of Medical Microbiology, Turku University, Finland.
The Journal of Rheumatology
|July 1, 1988
Abstract:
No homology was observed between Yersinia enterocolitica O:3 and HLA-B27 at DNA level when Yersinia enterocolitica chromosomal probes were hybridized with human HLA-B27 positive leukocyte DNA or in the hybridization of Yersinia DNA with HLA-B27 specific probe. Our results do not exclude the existence of molecular mimicry between Yersinia proteins and HLA-B27 antigen, since the crossreactive epitope might be a conformational determinant not detected with hybridization.