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Targeting the innate immune receptor TLR8 using small-molecule agents.

Kentaro Sakaniwa1, Toshiyuki Shimizu1

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Acta Crystallographica. Section D, Structural Biology
|July 7, 2020
PubMed
Summary

Toll-like receptor 8 (TLR8) recognizes RNA to trigger innate immunity. Structural analysis reveals how ligands activate or inhibit TLR8, with potential clinical uses for TLR8 modulators.

Keywords:
Toll-like receptorsagonistantagonistinnate immunitystructural biology

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