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Pulmonary function testing with tidal breath analyze technique is useful in predicting persistant small airway damage

Elif Çelik1, Pınar Uysal2

  • 1General Pediatrics Unit, Department of Pediatrics, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|July 7, 2020
PubMed

Insights

Infant lung function recovery after acute bronchiolitis is prolonged. Tidal breath analysis (TBA) effectively assesses infant pulmonary function and can predict lasting small airway damage.

Area of Science:

  • Pediatrics
  • Respiratory Medicine
  • Infant Health

Background:

  • Infant lung function assessment is challenging due to technical limitations.
  • Acute bronchiolitis (AB) is a common respiratory infection in infants.
  • This study addresses the need for better infant pulmonary function evaluation.

Purpose of the Study:

  • To investigate breathing parameters in infants hospitalized with acute bronchiolitis using tidal breath analysis (TBA).
  • To assess lung function recovery over 30 days post-treatment.
  • To explore the utility of TBA in predicting persistent airway damage.

Main Methods:

  • Prospective cross-sectional study involving 111 infants (1 month-2 years).
  • 61 infants diagnosed with AB, 50 healthy controls.
  • Tidal breath analysis (TBA) performed on days 1, 7, and 30 post-hospitalization.

Main Results:

  • Key lung function parameters (tPTEF, tPTEF:tE, VT/kg, tI/tE) remained significantly lower at 30 days post-disease onset.
  • The tPTEF:tE ratio correlated inversely with hospitalization duration and disease severity.
  • A strong correlation was observed between tPTEF:tE and VPTEF:VE (r = .876, P < .001).

Conclusions:

  • Pulmonary function recovery in the lower respiratory tract is a gradual process in infants post-AB.
  • Tidal breath analysis (TBA) is a practical and effective method for assessing infant lung function.
  • TBA can assist clinicians in identifying infants at risk for persistent small airway damage.
Abstract

Keywords:
acute bronchiolitisinfantlung functiontidal breath analysis

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