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Published on: November 16, 2015
[Hypertrophy of palatine tonsils - possible treatment approaches]
E P Karpova1, L V Gankovskaya2, O V Vozgoment1,3
1Russian Medical Academy for Continuing Professional Education of the Ministry of Health of Russia, Moscow, Russia.
Insights
Complex treatment including tonsillotomy and Polyoxidonium significantly improves nasal breathing and reduces infections in children with enlarged palatine tonsils (HPT). This approach enhances antimicrobial peptide gene expression, proving clinically effective and safe.
Area of Science:
- Pediatric Otolaryngology
- Immunology
- Pharmacology
Background:
- Hypertrophy of palatine tonsils (HPT) can lead to significant health issues in children.
- Evaluating treatment efficacy for HPT is crucial for improving patient outcomes.
Purpose of the Study:
- To assess the effectiveness of different treatment modalities for HPT in children.
- To compare tonsillotomy, conservative treatment with Polyoxidonium, and combined therapy.
Main Methods:
- A study involving 90 children with HPT (grades II-III) and 20 healthy controls.
- Treatment groups included tonsillotomy, topical Polyoxidonium, or combined therapy.
- Evaluated nasal breathing, respiratory infections, antimicrobial peptide gene expression, and spleen characteristics via ultrasound.
Main Results:
- Polyoxidonium alone improved nasal breathing, reduced infections, and increased antimicrobial peptide gene expression.
- Combined therapy (tonsillotomy + Polyoxidonium) showed superior results compared to tonsillotomy or Polyoxidonium alone.
- Comprehensive treatment significantly decreased nasal breathing issues and infection frequency.
Conclusions:
- The use of Polyoxidonium in complex HPT treatment is clinically effective.
- Combined therapy demonstrates significant benefits over individual treatments.
- Polyoxidonium is a safe and effective adjunct in managing HPT.
Objective:
To evaluate the effectiveness of different approaches to the treatment of patients with hypertrophy of the palatine tonsils (HPT).
Material And Methods:
90 children with HPT of II-III degree and 20 healthy children (group 1) aged from 3 to 7 years were included in the study. Children with HPT were divided into three groups: group 2 - children who underwent tonsillotomy (n=30), group 3 - children who underwent conservative treatment, including only topical use of Polyoxidonium (n=30), group 4 - children who underwent complex treatment (tonsillotomy with subsequent local use of Polyoxidonium), (n=30). The severity of nasal breathing disturbances on a visual analogue scale, the average number of acute respiratory viral infections 6 months before and after treatment, the level of gene expression of antimicrobial peptides before and after treatment, the degree of hypertrophy of the palatine tonsils and spleen with an assessment of the echostructure and determination of the spleen mass coefficient using Ultrasound were evaluated in the study.
Results:
In children receiving only Polyoxidonium, there was a decrease in the severity of nasal breathing disorders, a decrease in the frequency of acute respiratory viral infections, an increase in the expression of antimicrobial peptide genes compared to the initial level of these indicators. Comprehensive treatment of children with HPT (group 4) showed a significant decrease in the severity of nasal breathing disorders, a decrease in the average number of acute respiratory infections within 6 months, an increase in the expression of antimicrobial peptide genes compared to children who underwent only tonsillotomy (group 2) or only conservative therapy (group 3).
Conclusion:
It is proved that the use of Polyoxidonium in the complex treatment of HPT is clinically effective and safe.
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