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Updated: Dec 15, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Visible-Light-Mediated Intermolecular Radical Conjugate Addition for the Construction of Vicinal Quaternary Carbon
Lei Li1, Lili Fang1, Weiping Wu1
1School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University, Nanjing 210023, China.
Abstract:
The visible light-driven organophotoredox catalysis is reported for the construction of vicinal quaternary carbon centers. Intermolecular conjugate addition of alkyl radicals, derived from 2,2-disubstituted dihydroquinazolinones, to Michael acceptors under blue light irradiation and rhodamine B catalysis allows the facile assembly of diverse, vicinal secondary/quaternary, tertiary/quaternary, and quaternary/quaternary carbon centers at room temperature. Our method provides a synthetically versatile protocol since both 2,2-disubstituted dihydroquinazolinones and Michael acceptors can be conveniently prepared from readily available ketones.
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