Two-dimensional nanocomposite-based electrochemical sensor for rapid determination of trans-resveratrol

A two-dimensional nanocomposite-based disposable electrochemical sensor was fabricated for the rapid analysis of trans-resveratrol (TRA) in red wine. The sensor was prepared by modifying graphene-molybdenum disulfide (Gr-MoS₂) nanocomposite on the surface of screen-printed electrode (SPE). Results show that the Gr-MoS₂ nanocomposite with sheet-on-sheet structure can accelerate the oxidation reaction kinetics of TRA due to its large effective electrochemical surface area and high electron transfer rate. As a result, the Gr-MoS₂ nanocomposite appears the synergistic effects, making the highly sensitive detection of TRA come true. The prepared sensor showed a linear response in TRA concentration from 1.0 to 200 μmol L^-1 (with a limit of detection of 0.45 μmol L^-1). After validating the accuracy with high performance liquid chromatography (HPLC), this nanocomposite-based electrochemical sensor can be applied for the detection of TRA in real red wine samples.