Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to Letter to the editor to comment on "Is arthroscopically-assisted reduction and internal fixation (ARIF) superior to percutaneous fixation in talar neck fractures? A proportional meta-analysis".

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons·2026
Same author

PEG-β-Cyclodextrin polymer-based formulation to increase the antiangiogenic activity of rutin in vivo.

International journal of pharmaceutics·2026
Same author

Is arthroscopically-assisted reduction and internal fixation (ARIF) superior to percutaneous fixation in talar neck fractures? A proportional meta-analysis.

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons·2026
Same author

Diroximel Fumarate-Loaded Solid Lipid Nanoparticles (DRF-SLNs) as Potential Carriers for the Treatment of Multiple Sclerosis: Preformulation Study.

International journal of molecular sciences·2025
Same author

The Effects of a Modified Mediterranean Diet on Gut Microbiota and Chemotherapy Side Effects in Patients With Metastatic Colorectal Cancer Undergoing First-Line Chemotherapy With or Without Either Antiepidermal Growth Factor Receptor or Antivascular Endothelial Growth Factor Agent: Protocol for a Randomized Pilot Study in Italy.

JMIR research protocols·2025
Same author

Design of Polycation-Functionalized Resveratrol Nanocrystals for Intranasal Administration.

Pharmaceutics·2025
Same journal

RETRACTED: Atta et al. Effect of Montmorillonite Nanogel Composite Fillers on the Protection Performance of Epoxy Coatings on Steel Pipelines. <i>Molecules</i> 2017, <i>22</i>, 905.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Chen et al. Chemical Composition of <i>Litsea pungens</i> Essential Oil and Its Potential Antioxidant and Antimicrobial Activities. <i>Molecules</i> 2023, <i>28</i>, 6835.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Zueva et al. Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry. <i>Molecules</i> 2020, <i>25</i>, 1371.

Molecules (Basel, Switzerland)·2026
Same journal

1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications.

Molecules (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Dec 15, 2025

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.3K

Curcumin Containing PEGylated Solid Lipid Nanoparticles for Systemic Administration: A Preliminary Study.

Debora Santonocito1, Maria Grazia Sarpietro1, Claudia Carbone1

  • 1Department of Drug Sciences, University of Catania, Viale Andrea Doria n°6, 95125 Catania, Italy.

Molecules (Basel, Switzerland)
|July 8, 2020
PubMed
Summary
This summary is machine-generated.

Stealth solid lipid nanoparticles (SLNs) successfully encapsulated curcumin, enhancing its potential for systemic delivery. These curcumin-loaded pSLNs demonstrate promising stability and antioxidant activity for treating central nervous system (CNS) conditions.

Keywords:
ORACPEGylationSLNTEMTurbiscancryoprotectorcurcuminstealth system

More Related Videos

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

24.9K
Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

9.3K

Related Experiment Videos

Last Updated: Dec 15, 2025

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.3K
Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

24.9K
Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

9.3K

Area of Science:

  • Nanotechnology
  • Pharmacology
  • Materials Science

Background:

  • Curcumin (CUR) exhibits significant anti-inflammatory and antioxidant properties, making it a potential therapeutic agent for central nervous system (CNS) diseases.
  • High lipophilicity limits curcumin's clinical application, while conventional solid lipid nanoparticles (SLNs) suffer from short systemic half-lives.
  • Stealth SLNs (pSLNs) offer a strategy to improve the systemic delivery and therapeutic efficacy of lipophilic drugs like curcumin.

Purpose of the Study:

  • To formulate and characterize curcumin-loaded stealth solid lipid nanoparticles (pSLNs) for enhanced systemic administration.
  • To evaluate the technological properties, antioxidant activity, and long-term stability of the developed curcumin-loaded pSLNs.
  • To assess the potential of pSLNs as a viable nanocarrier system for curcumin delivery.

Main Methods:

  • Curcumin-loaded pSLNs were prepared using the solvent evaporation method.
  • Formulations were characterized for particle size, zeta potential, size distribution, and morphology (TEM).
  • Antioxidant activity was assessed using the Oxygen Radical Absorbance Capacity (ORAC) assay, and long-term stability was analyzed. Differential Scanning Calorimetry (DSC) was used to confirm PEG interaction.

Main Results:

  • Curcumin-loaded pSLNs exhibited favorable technological parameters, with a mean particle size under 200 nm and a zeta potential of approximately -30 mV.
  • TEM images confirmed the particle size, and DSC analysis indicated successful interaction and surface localization of PEG micelles.
  • The formulation demonstrated good long-term stability and retained the antioxidant activity of curcumin.

Conclusions:

  • The developed curcumin-loaded pSLNs possess suitable characteristics for effective systemic administration.
  • The stealth modification of SLNs effectively addresses limitations associated with drug lipophilicity and nanoparticle half-life.
  • This formulation represents a promising nanocarrier for the systemic delivery of curcumin, potentially advancing its therapeutic use in CNS pathologies.