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Updated: Dec 15, 2025

Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

70.8K

Reactive Oxygen Species and Antitumor Immunity-From Surveillance to Evasion

Andromachi Kotsafti1, Marco Scarpa2, Ignazio Castagliuolo3

  • 1Laboratory of Advanced Translational Research, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.

Cancers
|July 8, 2020
PubMed

Insights

Reactive oxygen species (ROS) significantly influence the immune system's fight against tumors by affecting cancer antigenicity and the tumor microenvironment. Understanding ROS's complex role is key for developing new cancer immunotherapies.

Area of Science:

  • Immunology
  • Oncology
  • Biochemistry

Background:

  • The immune system critically influences tumor progression, either promoting or suppressing cancer.
  • Reactive oxygen species (ROS) are increasingly recognized for their dual role in oxidative stress and immune regulation during tumor development.

Purpose of the Study:

  • To review the mechanisms by which ROS impact anti-tumor immune responses.
  • To emphasize the role of ROS in cancer antigenicity, immunogenicity, and the tumor immune microenvironment.

Main Methods:

  • Literature review of existing research on ROS and the immune system in cancer.
  • Analysis of the molecular and cellular pathways affected by ROS in the tumor microenvironment.

Main Results:

  • ROS modulate cancer antigen presentation and immune cell function within the tumor microenvironment.
  • ROS influence the balance between pro-tumor and anti-tumor immune responses.

Conclusions:

  • ROS play a complex, multifaceted role in cancer immunity.
  • Targeting ROS in conjunction with immunotherapies may offer novel strategies for cancer treatment.
Keywords:
cancerimmunityinflammationoxidative stressreactive oxygen species

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