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The Many Faces of Matrix Metalloproteinase-7 in Kidney Diseases

Zhao Liu1, Roderick J Tan2, Youhua Liu1,3

  • 1State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Biomolecules
|July 8, 2020
PubMed

Insights

Matrix metalloproteinase-7 (MMP-7) is a key enzyme in kidney health and disease. This review explores MMP-7

Area of Science:

  • Nephrology
  • Molecular Biology
  • Biochemistry

Background:

  • Matrix metalloproteinase-7 (MMP-7) is a secreted enzyme crucial for kidney homeostasis.
  • MMP-7 expression is low in healthy kidneys but elevated in acute kidney injury (AKI) and chronic kidney disease (CKD).
  • Its regulation involves Wnt/β-catenin signaling and other factors.

Purpose of the Study:

  • To review recent advances in understanding MMP-7's regulation and role in kidney disease pathogenesis.
  • To discuss MMP-7's potential as a noninvasive biomarker and therapeutic target.

Main Methods:

  • Literature review of studies on MMP-7 in kidney physiology and pathology.
  • Analysis of MMP-7's substrates and downstream cellular effects.
  • Evaluation of MMP-7's diagnostic and therapeutic potential.

Main Results:

  • MMP-7 cleaves extracellular matrix components and other substrates like E-cadherin and nephrin.
  • It influences cell proliferation, apoptosis, epithelial-mesenchymal transition, and podocyte injury.
  • MMP-7 has dual roles: protective in AKI but detrimental in CKD fibrosis and proteinuria.

Conclusions:

  • MMP-7's function in kidney disease is complex and context-dependent.
  • Urinary MMP-7 levels can serve as a biomarker for AKI prognosis and CKD monitoring.
  • MMP-7 presents a potential therapeutic target for kidney diseases.
Keywords:
acute kidney injuryapoptosischronic kidney diseasefibrosismatrix metalloproteinase-7proteinuria

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