Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent Caffeine Drinking Associates with Cognitive Function in the UK Biobank.

Marilyn C Cornelis1, Sandra Weintraub2,3, Martha Clare Morris4

  • 1Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Nutrients
|July 8, 2020
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuropathology-specific language features in primary progressive aphasia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Trajectories of brain structure and function in young adult carriers of genetic frontotemporal dementia variants.

medRxiv : the preprint server for health sciences·2026
Same author

Syndrome-specific vulnerability of neuronal and glial 4-repeat frontotemporal lobar degeneration-tau.

Brain : a journal of neurology·2026
Same author

Effects of age and APOE ϵ4 genotype on the relationship between pulse pressure and executive function in older adults without Dementia.

Journal of the International Neuropsychological Society : JINS·2026
Same author

Factors influencing accelerated progression in behavioral variant frontotemporal dementia.

Journal of neurology·2026
Same author

Identifying neuropathologic disease in primary progressive aphasia using narrative speech.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Recent caffeine intake improved reaction times but impaired memory and reasoning in UK Biobank participants. These cognitive effects varied by task, highlighting the complex relationship between caffeine and brain function.

Area of Science:

  • Cognitive Neuroscience
  • Human Genetics
  • Nutritional Psychiatry

Background:

  • Clinical studies suggest caffeine benefits cognition, but real-world effects and influencing factors like metabolism remain unclear.
  • Understanding caffeine's impact requires examining lifestyle and genetic predispositions in diverse populations.

Purpose of the Study:

  • To investigate the acute effects of caffeine consumption on cognitive performance.
  • To explore how lifestyle and genetic factors modify the relationship between caffeine and cognition.

Main Methods:

  • Utilized UK Biobank data from over 434,900 participants (aged 37-73).
  • Assessed recent caffeine intake (yes/no) and cognitive functions: reaction time, prospective memory, pairs matching, and fluid intelligence.
  • Employed multivariable regressions and tested interactions with a genetic caffeine-metabolism score (CMS).
Keywords:
acutecaffeinecognitioncohortgenotypememoryreaction time

Related Experiment Videos

Main Results:

  • Recent caffeine intake was linked to faster reaction times but poorer performance in fluid intelligence, pairs matching, and prospective memory among white participants.
  • Similar trends were observed in non-white participants for fluid intelligence and pairs matching.
  • No significant modification of effects by age, sex, smoking, test time, habitual intake, or CMS was found.

Conclusions:

  • Caffeine may enhance performance on tasks requiring quick reactions.
  • Potential detrimental effects of recent caffeine consumption on memory and reasoning necessitate further investigation.
  • The study underscores the nuanced impact of acute caffeine intake on diverse cognitive domains.