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Nonconsensual Dose Reduction Mandates are Not Justified Clinically or Ethically: An Analysis.
Stefan G Kertesz1, Ajay Manhapra1, Adam J Gordon1
1Stefan G. Kertesz, M.D., M.Sc., is a professor at the Department of Medicine, UAB School of Medicine and research investigator at the Birmingham VA Medical Center. He is a board-certified internal medicine (American Board of Internal Medicine) and addiction medicine physician (American Board of Addiction Medicine). His research career began in 2000 and he has been funded by both the National Institute on Drug Abuse and the Health Services Research & Development Branch of the Department of Veterans Affairs. He received his MD from Harvard Medical School in Boston, MA and his MSc from Boston University School of Public Health in Boston, MA. Ajay Manhapra, M.D., is Lecturer at Yale School of Medicine in the Department of Psychiatry, Assistant Professor, at the Eastern Virginia Medical School in the Department of Physical Medicine and Rehabilitation and Psychiatry, and Research Scientist at the VA New England Mental Illness Research, Education and Clinical Center. Dr. Manhapra is a board-certified Internist and Addiction Medicine physician with educational, clinical and research focus on pain and addiction. He runs a unique clinic for recovering patients with severe disabling chronic pain and medication or substance dependence at Hampton VA Medical Center, where he is developing an interdisciplinary integrative model for treatment of pain and addiction. Dr. Manhapra received his medical degree from Government Medical College, Thrissur, Kerala, India, and completed his Addiction Medicine fellowship at Yale School of Medicine. Adam J. Gordon, M.D., M.P.H., is Professor of Medicine and Psychiatry at the University of Utah School of Medicine, Director of the Program for Addiction Research, Clinical Care, Knowledge, and Advocacy (PARCKA), and Chief of Addiction Medicine at VA Salt Lake City Health Care System and. He is a board-certified internal medicine (American Board of Internal Medicine) and addiction medicine physician (American Board of Preventive Medicine) with a 20-year track record of conducting research on the quality, equity, and efficiency of health care for vulnerable populations (e.g., persons with opioid use disorders, persons who are homeless, persons with hazardous alcohol use and other addiction disorders). He received his MD from University of Pittsburgh School of Medicine in Pittsburgh, PA and his MPH from the University of Pittsburgh Graduate School of Public Health in Pittsburgh, PA.
Mandating opioid dose reduction for long-term patients lacks clinical evidence and safety justification. Healthcare providers face pressure, but policy incentives for forced reduction are not supported by guidelines or data.
Area of Science:
- Clinical Medicine
- Public Health Policy
- Pain Management
Background:
- Rising opioid addiction and overdose rates necessitate a re-evaluation of long-term opioid therapy.
- Healthcare providers are experiencing a clinical recalibration regarding opioid prescribing practices.
- Policy-making agencies are creating incentives for mandatory opioid dose reduction.
Purpose of the Study:
- To examine the institutional and clinical considerations surrounding mandated opioid dose reduction for long-term opioid users.
- To assess the safety and efficacy of policies advocating for forced opioid dose reduction.
Main Methods:
- Review of institutional policies and clinical guidelines related to long-term opioid therapy.
- Analysis of the evidence base supporting or refuting mandated opioid dose reduction.
- Examination of the impact of the 2016 Centers for Disease Control and Prevention (CDC) Guideline.
Main Results:
- Current clinical evidence and guidelines, including the 2016 CDC Guideline, do not support mandated opioid dose reduction as safe or effective.
- Institutional and policy pressures may not align with clinical evidence for long-term opioid management.
Conclusions:
- Mandatory opioid dose reduction for patients on long-term opioid therapy is not supported by scientific evidence or clinical guidelines.
- Policies favoring forcible reduction may pose risks and are not justified by current data, necessitating careful clinical consideration.
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