[Natural killer cells lysing the blood B-lymphocytes of patients with chronic lympholeukemia]

The results of the study of natural cytotoxic activity of human peripheral blood lymphocytes are presented. Two types of natural killer cells isolated in discontinuous percoll density gradient have been shown to exist. Lymphocytes with low floating density lyse NK-sensitive target cells and leukemic B-lymphocytes, increase the lytic activity with respect to blasts of K-562 line under the effect of alpha-interferon. Lymphocytes isolated in percoll heavy fractions chiefly lyse leukemic B cells of patients by B-variant CLL and are not sensitive to the alpha-interferon effect.