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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
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AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
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Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
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Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

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Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
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Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
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Updated: Dec 15, 2025

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
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[Mesalazine renal lithiasis.]

Alberto Vílchez1, Juan Antonio Orts1, Sarah Frédérique Scheirs2

  • 1Área de Diagnóstico Biológico. Hospital Universitario de la Ribera. Alzira. Valencia. España.

Archivos Espanoles De Urologia
|July 8, 2020
PubMed
Summary

High-dose mesalazine may cause kidney stones (nephrolithiasis), a rare but serious adverse effect. This drug-induced lithiasis is often underdiagnosed and not listed in patient information leaflets.

Keywords:
Análisis morfoconstitucionalLitiasis renalMesalazinaMesalazineMorpho- constitutional analysisNephrolithiasis

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Area of Science:

  • Nephrology
  • Pharmacology
  • Gastroenterology

Background:

  • Mesalazine (5-aminosalicylic acid, 5-ASA) is a primary treatment for inflammatory bowel disease.
  • Nephritic colic is a known rare side effect, but mesalazine-induced nephrolithiasis is infrequently reported.

Purpose of the Study:

  • To report two cases of mesalazine-induced nephrolithiasis.
  • To highlight the importance of considering drug-induced lithiasis in patients on high-dose mesalazine therapy.

Main Methods:

  • Case report of two patients treated with high-dose mesalazine.
  • Analysis of calculi composition (methodology not specified in abstract).

Main Results:

  • Two patients developed kidney stones while receiving high-dose mesalazine.
  • Mesalazine nephrolithiasis may be underdiagnosed due to inadequate diagnostic methods.

Conclusions:

  • High-dose mesalazine can lead to drug-induced nephrolithiasis.
  • This adverse effect should be recognized and investigated, even if not listed in product information.