Regioselective Difunctionalization of 2,6-Difluorophenols Triggered by Sigmatropic Dearomatization
Koichi Okamoto1, Keisuke Nogi1, Hideki Yorimitsu1
1Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
Abstract:
Regioselective difunctionalization of 2,6-difluorophenols with aryl sulfoxides and nucleophiles has been accomplished. The reaction is composed of (1) Pummerer-based [3,3] sigmatropic dearomatization to generate 2,4-cyclohexadienone, (2) Michael addition of a nucleophile, and (3) liberation of HF for rearomatization. Besides the [3,3] rearrangement, [2,3] sigmatropic rearrangement from sulfonium ylide generated from alkyl sulfoxide promotes the dearomatization, resulting in installation of α-sulfanylalkyl group.
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