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The influence of the gastrointestinal microbiome on infant colic

Abdelhalim Ouald Chaib1, Elvira Ingrid Levy1, Mariam Ouald Chaib1

  • 1KidZ Health Castle, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel , Brussels, Belgium.

Expert Review of Gastroenterology & Hepatology
|July 8, 2020
PubMed

Insights

Infantile colic may be linked to an imbalanced gut microbiome. Further research into the gastrointestinal microbiome could reveal causes and treatments for colic in infants.

Area of Science:

  • Gastroenterology
  • Microbiology
  • Pediatrics

Background:

  • Infantile colic is a common condition with unknown pathophysiology.
  • The gastrointestinal microbiome's role in colic is increasingly recognized.

Purpose of the Study:

  • To explore the connection between infantile colic and the gastrointestinal microbiome.
  • To understand how gut microbiome alterations may contribute to colic symptoms.

Main Methods:

  • Literature review of scientific databases (PubMed, Google Scholar) up to February 2020.
  • Analysis of factors influencing microbiome development and dysbiosis.
  • Examination of potential mechanisms linking microbiome to colic.

Main Results:

  • Gut microbiome composition is associated with infantile colic development.
  • Dysbiosis can lead to increased gas production and gut inflammation.
  • Probiotic Lactobacillus reuteri DSM17938 shows efficacy in breastfed infants with colic.

Conclusions:

  • The gastrointestinal microbiome composition is linked to infantile colic.
  • Further research, including species-level microbiome analysis, may elucidate colic's etiology and management.
  • Targeting the microbiome presents a potential therapeutic avenue for infantile colic.
Abstract

Keywords:
Microbiomedysbiosisinfantile coliclactobacillus reuterioligosaccharideprobiotic

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