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The OXTR polymorphisms are not associated with attachment dimensions: A three-approach study.

Pingyuan Gong1, Quanhe Wang2, Jinting Liu3

  • 1Shaanxi Key Laboratory for Animal Conservation, Northwest University, Xi'an, 710069, China; College of Life Science, Northwest University, Xi'an, 710069, China; College of Medicine, Northwest University, Xi'an, 710069, China.

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Summary

This study investigated the oxytocin receptor gene (OXTR) and its link to human attachment styles. Findings across three studies, including a meta-analysis, reveal no significant association between OXTR polymorphisms and attachment dimensions.

Keywords:
Attachment dimensionCross-sectional analysisMeta-analysisOxytocin receptor geneThree-wave analysis

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Area of Science:

  • Behavioral Genetics
  • Neuroscience
  • Psychology

Background:

  • Oxytocin influences social behaviors, prompting research into its receptor gene (OXTR) and human attachment.
  • Previous studies show conflicting results regarding the association between OXTR and attachment.

Purpose of the Study:

  • To clarify the relationship between OXTR gene polymorphisms and human attachment dimensions.
  • To consolidate evidence through integrated studies and meta-analysis.

Main Methods:

  • Cross-sectional study of college students (N=1193) examining OXTR polymorphisms (rs53576, rs2254298) and attachment.
  • Three-wave longitudinal study of freshmen (N=657) on OXTR polymorphisms and attachment changes.
  • Meta-analysis of published data on OXTR polymorphisms (rs53576, rs2254298) and attachment anxiety/avoidance.

Main Results:

  • No significant association was found between OXTR polymorphisms (rs53576, rs2254298) and attachment dimensions in the cross-sectional study.
  • The longitudinal study also found no association between OXTR polymorphisms and individual differences or changes in attachment.
  • Meta-analysis confirmed no significant link between rs53576 or rs2254298 polymorphisms and attachment anxiety or avoidance.

Conclusions:

  • The integrated findings provide robust evidence against a relationship between OXTR polymorphisms and human attachment dimensions.
  • This research contributes to resolving controversies surrounding the genetic underpinnings of attachment.