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Updated: Dec 15, 2025

Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells
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DNA Repair and Prostate Cancer: A Field Ripe for Harvest

Alan H Bryce1, Oliver Sartor2, Johann de Bono3

  • 1Department of Oncology, Mayo Clinic, Scottsdale, AZ, USA.

European Urology
|July 9, 2020
PubMed

Insights

Poly (ADP-ribose) polymerase (PARP) inhibitors show antitumor activity in prostate cancer. Two PARP inhibitors are FDA-approved for metastatic castrate-resistant prostate cancer, with more in clinical trials.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Metastatic castrate-resistant prostate cancer (mCRPC) remains a significant clinical challenge.
  • DNA repair defects are increasingly recognized as actionable targets in mCRPC.

Discussion:

  • Poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated promising antitumor activity in mCRPC.
  • The efficacy of PARP inhibitors is linked to specific DNA repair gene alterations.

Key Insights:

  • Olaparib and rucaparib are US Food and Drug Administration (FDA)-approved for mCRPC with select DNA repair defects.
  • Ongoing clinical trials are evaluating talazoparib, veliparib, and niraparib in prostate cancer.

Outlook:

  • Further advancements in PARP inhibitor therapy are anticipated for prostate cancer treatment.
  • Personalized medicine approaches targeting DNA repair pathways will likely expand.

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