Epimerization of ergot alkaloids in feed
Claude Schummer1, Irène Zandonella1, An van Nieuwenhuyse1
1Laboratoire National de Santé, Service de Surveillance Alimentaire, 1, rue Louis Rech, 3555 Dudelange Luxembourg.
Heliyon
|July 9, 2020
Summary
Ergot alkaloids in contaminated cereals can cause ergotism in livestock. Processing methods like heating, solvents, or UV light do not significantly alter ergot alkaloid composition to make toxic feed safe.
Area of Science:
- Agricultural Science
- Veterinary Medicine
- Food Chemistry
Background:
- Ergot alkaloids from contaminated cereals cause ergotism, a significant issue in livestock.
- Ergotism symptoms include loss of digits and can be fatal.
- Only the R-form of ergot alkaloids is toxic, and epimerization mechanisms are poorly understood.
Purpose of the Study:
- To evaluate the influence of different processing methods on ergot alkaloid epimerization.
- To determine if processing can reduce the toxicity of contaminated feed.
Main Methods:
- Exposure of ergot alkaloids to heating, protic solvents, and UV light.
- Analysis of ergot alkaloid concentrations and R/S ratios before and after processing.
Main Results:
- Ergotamine and ergosine showed high stability, unaffected by processing.
- Heating, solvents, and UV light influenced the R/S ratio of ergocristine, ergokryptine, ergocornine, and ergometrine towards the S-form.
- Heating reduced total ergot alkaloid concentrations but did not detoxify feed.
Conclusions:
- Processing methods have limited impact on the epimerization and overall composition of ergot alkaloids in feed.
- Current processing techniques are insufficient to transform toxic feed into non-toxic feed for livestock.
Keywords:
EpimerizationErgot alkaloidsFeed processingFood analysisFood safetyFood technologyUPLC-MS/MSMore Related Videos
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