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Related Concept Videos

Collagens are the Major Structural Proteins of ECM01:13

Collagens are the Major Structural Proteins of ECM

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Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
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Liver Regeneration01:24

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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Liver Physiology01:30

Liver Physiology

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
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Type IV Collagen of Basal Lamina01:05

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Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
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Fibril-associated Collagen01:11

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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
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Liver Histology

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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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Related Experiment Video

Updated: Dec 15, 2025

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis
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3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis

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The liver matrisome - looking beyond collagens.

Gavin E Arteel1,2, Alexandra Naba3,4

  • 1Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

JHEP Reports : Innovation in Hepatology
|July 9, 2020
PubMed
Summary
This summary is machine-generated.

The matrisome, or extracellular matrix (ECM), regulates tissue homeostasis. Studying its complex changes in liver fibrosis may reveal new disease insights and biomarkers.

Keywords:
AUROC, area under the receiver operating characteristic curveCCl4, carbon tetrachlorideECMECM, extracellular matrixExtracellular matrixFibrosisHCC, hepatocellular carcinomaLiver diseaseMMP, matrix metalloproteinaseNAFLD, non-alcoholic fatty liver diseaseNPV, negative predictive valuePOSTN, periostinPPV, positive predictive valuesProteomicsRegenerationTGFβ, transforming growth factor beta

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Related Experiment Videos

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3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis
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Area of Science:

  • Biochemistry
  • Cell Biology
  • Pathology

Background:

  • The extracellular matrix (ECM) is crucial for cell communication and tissue homeostasis.
  • The 'matrisome' encompasses ECM proteins, regulating tissue structure, growth factor storage, and cell signaling.
  • Dysregulation of the matrisome contributes to diseases like hepatic fibrosis.

Purpose of the Study:

  • To review the role of the ECM in liver diseases.
  • To explore novel 'omic' approaches for studying the hepatic matrisome.
  • To understand the diverse alterations in the hepatic matrisome during fibrosis.

Main Methods:

  • Literature review focusing on ECM and matrisome in liver disease.
  • Discussion of emerging 'omic' technologies (genomics, proteomics, etc.).
  • Analysis of qualitative and quantitative changes in the hepatic matrisome.

Main Results:

  • Hepatic fibrosis involves more than collagen accumulation; diverse matrisome alterations occur early.
  • The matrisome dynamically responds to stress and injury, with maladaptive changes leading to disease.
  • Understanding these changes offers insights into disease mechanisms.

Conclusions:

  • The hepatic matrisome is a key player in liver disease progression and regression.
  • Investigating the matrisome can identify novel biomarkers for liver fibrosis.
  • Advanced 'omic' approaches are essential for comprehensive matrisome analysis.