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Circulating Markers of Angiogenesis and Endotheliopathy in COVID-19
Matthew L Meizlish1, Alexander B Pine2, George Goshua2
1Yale School of Medicine, New Haven, Connecticut.
Insights
This study identified increased markers of angiogenesis and endotheliopathy in hospitalized COVID-19 patients. These vascular factors may help explain the varying severity and outcomes of coronavirus disease 2019.
Area of Science:
- Cardiovascular Medicine
- Infectious Diseases
- Pathophysiology
Background:
- The pathophysiological factors driving COVID-19 clinical outcome variability remain unclear.
- Patients with cardiovascular disease exhibit poorer outcomes, with autopsy studies noting endotheliopathy and angiogenesis.
- Reliable circulating vascular markers for COVID-19 severity and mortality are lacking.
Approach:
- Plasma profiling of vascular factors in PCR-confirmed COVID-19 patients admitted to Yale-New Haven Hospital.
- Analysis focused on identifying differences in vascular markers between hospitalized patients and controls.
Key Points:
- Hospitalized COVID-19 patients show significantly increased plasma markers of angiogenesis.
- Elevated markers of endotheliopathy were also observed in hospitalized COVID-19 patients.
- These findings suggest a role for vascular dysfunction in COVID-19 pathogenesis.
Conclusions:
- Increased angiogenesis and endotheliopathy markers are associated with hospitalization in COVID-19.
- These vascular markers may serve as indicators of disease severity.
- Further research into vascular dysfunction can elucidate COVID-19 pathogenesis and inform treatment strategies.
Abstract:
Despite over 9.3 million infected and 479,000 deaths, the pathophysiological factors that determine the wide spectrum of clinical outcomes in COVID-19 remain inadequately defined. Importantly, patients with underlying cardiovascular disease have been found to have worse clinical outcomes,1 and autopsy findings of endotheliopathy as well as angiogenesis in COVID-19 have accumulated.2,3 Nonetheless, circulating vascular markers associated with disease severity and mortality have not been reliably established. To address this limitation and better understand COVID-19 pathogenesis, we report plasma profiling of factors related to the vascular system from a series of patients admitted to Yale-New Haven Hospital with confirmed diagnosis of COVID-19 via PCR, which demonstrate significant increase in markers of angiogenesis and endotheliopathy in patients hospitalized with COVID-19.
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