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[Initial experiences with propofol (Disoprivan) for anesthesia induction in pediatric anesthesia]
J Motsch1, W Must, K Hutschenreuter
1Institut für Anaesthesie, Universitätskliniken des Saarlandes, Homburg.
Der Anaesthesist
|September 1, 1988
Summary
Propofol provides smooth anesthesia induction and rapid recovery in children. While generally safe, it can cause transient cardiovascular changes and respiratory depression, with some injection site discomfort reported.
Area of Science:
- Anesthesiology
- Pediatric Anesthesia
- Pharmacology
Context:
- Propofol is an intravenous anesthetic with rapid induction and recovery.
- Limited data exists on propofol's use in pediatric anesthesia.
- This study addresses the need for more pediatric-specific data.
Purpose:
- To evaluate propofol's cardiovascular and respiratory effects in children.
- To assess the incidence of side-effects during pediatric anesthesia induction with propofol.
Summary:
- Propofol (2.5 mg/kg) induced anesthesia smoothly and rapidly in 25 children (3-12 years).
- Mean arterial pressure decreased by up to 16.8%. Heart rate showed variable changes.
- Respiratory depression (decreased SaO2) occurred, but no apnea. Injection site pain/discomfort was noted in some patients.
Impact:
- Provides crucial data on propofol's safety and efficacy in pediatric patients.
- Informs anesthetic practice for children undergoing procedures.
- Highlights potential side effects for improved patient management.