Related Experiment Video
Updated: Dec 15, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Exploiting fluorescent zinc(ii) and copper(ii) complexes for enantiomeric excess determination of hydroxycarboxylates
Sara Sheykhi1, Lorenzo Mosca, Mariia Pushina
1Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA. pavel@bgsu.edu.
Abstract:
Chiral hydroxycarboxylates are useful compounds in the syntheses of natural products, pharmaceutical intermediates, and drugs. Here, we report on Zn- and Cu-containing sensors that can distinguish between enantiomers of hydroxycarboxylates through the quenching or the enhancement of fluorescence. A Zn-based sensor-[ZnRRL]2+-is used in an assay to perform analyses of enantiomeric excess (% ee) of scalemic mixtures of α-hydroxycarboxylates and various drugs including the statin drug atorvastatin. This assay enables determination of mixtures of enantiomers across the range from 0 to 100% ee.
Related Concept Videos
Extraction: Advanced Methods
Complexometric Titration: Overview

