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Updated: Dec 15, 2025
Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue
Published on: August 28, 2021
Large-Scale Proteomics Highlights Glial Role in Neurodegeneration
Alexei Verkhratsky1, Robert Zorec2
1Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK; Achucarro Center for Neuroscience, IKERBASQUE, 48011 Bilbao, Spain.
Abstract:
Recent quantitative mass spectrometry and coexpression network analysis of postmortem human brain samples identified protein networks responsible for sugar metabolism and function of astrocytes and microglia are altered in Alzheimer's disease and other types of neurodegenerative disorders. Boosting neuroglial function may represent a new strategy for containing neurodegeneration.
