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NRF2, a Transcription Factor for Stress Response and Beyond
Feng He1, Xiaoli Ru2, Tao Wen3
1Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
International Journal of Molecular Sciences
|July 10, 2020
Summary
Nuclear factor erythroid 2-related factor 2 (NRF2) is a key transcription factor regulating cellular defense against oxidative stress and detoxification. Its complex network controls cellular adaptation, impacting metabolism and inflammation-related diseases.
Area of Science:
- Molecular Biology
- Cellular Biology
- Biochemistry
Background:
- Nuclear factor erythroid 2-related factor 2 (NRF2) is a crucial transcription factor.
- NRF2 orchestrates cellular defense against oxidative stress and toxic insults.
- Its role extends beyond antioxidant responses to metabolism and inflammation.
Purpose of the Study:
- To summarize the intricate regulatory network of NRF2 activity.
- To elucidate NRF2's multifaceted roles in cellular processes.
- To highlight NRF2's significance in maintaining homeostasis and disease adaptation.
Main Methods:
- Review of existing literature on NRF2 regulation and function.
- Analysis of NRF2's involvement in various cellular pathways.
- Synthesis of evidence regarding NRF2's pleiotropic effects.
Main Results:
- NRF2 activity is precisely controlled by transcriptional and post-translational mechanisms.
- NRF2 plays a central role in metabolic reprogramming, proteostasis, and inflammation.
- Dysregulation of NRF2 is linked to metabolism- and inflammation-related diseases.
Conclusions:
- NRF2 is a pleiotropic transcription factor with broad cellular functions.
- Understanding NRF2's regulatory network is vital for addressing various pathological conditions.
- NRF2's involvement in homeostasis maintenance and adaptation to stressors is critical.
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