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Mechanical Protein Functions01:58

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Related Experiment Video

Updated: Dec 15, 2025

Reconstitution of Msp1 Extraction Activity with Fully Purified Components
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METTL3 plays multiple functions in biological processes.

Shuiping Liu1,2, Lvjia Zhuo1,2, Jianjun Wang1

  • 1Holistic Integrative Pharmacy Institutes of Medicine School, Department of Respiratory Medicine of Affiliated Hospital, Hangzhou Normal University Hangzhou 311121, Zhejiang, China.

American Journal of Cancer Research
|July 10, 2020
PubMed
Summary
This summary is machine-generated.

Methyltransferase-like 3 (METTL3) is a key regulator of RNA modifications. This review summarizes METTL3

Keywords:
METTL3biological processcancer therapydiagnostic biomarkerm6A modification

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Area of Science:

  • Epigenetics
  • Molecular Biology
  • Biochemistry

Background:

  • N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotic messenger RNAs (mRNAs).
  • Methyltransferase-like 3 (METTL3) is the primary enzyme responsible for catalyzing m6A methylation.
  • METTL3 plays a crucial role in regulating gene expression beyond its catalytic activity, impacting mRNA translation and other cellular processes.

Purpose of the Study:

  • To systematically review and summarize the diverse biological roles and molecular mechanisms of METTL3.
  • To highlight the involvement of METTL3 in fundamental cellular processes.
  • To explore the potential of METTL3 as a diagnostic biomarker and therapeutic target in human cancers.

Main Methods:

  • Systematic literature review of recent studies on METTL3.
  • Analysis of experimental data and findings related to METTL3 functions.
  • Synthesis of information on METTL3's roles in various biological processes.

Main Results:

  • METTL3 is implicated in regulating cell cycle progression, proliferation, apoptosis, migration, invasion, differentiation, and inflammatory responses.
  • Emerging evidence demonstrates METTL3's multifaceted functions in diverse cellular contexts.
  • The review consolidates current knowledge on METTL3's impact across multiple biological pathways.

Conclusions:

  • METTL3 is a critical epigenetic regulator with significant roles in various cellular functions.
  • Understanding METTL3's mechanisms offers insights into fundamental biological processes.
  • METTL3 presents promising potential as a biomarker and therapeutic target for cancer treatment.