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Updated: Dec 15, 2025

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
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Supporting data on prion protein translocation mechanism revealed by pulling force studies

Theresa Kriegler1, Sven Lang2, Luigi Notari3

  • 1Department of Biochemistry and Biophysics Arrhenius Laboratories of Natural Sciences, Stockholm University, Svante Arrhenius väg 16C, SE-10691 Stockholm, Sweden.

Data in Brief
|July 10, 2020
PubMed
Summary

This study reveals the pulling force profile of prion protein (PrP) during its ER insertion using arrest peptide-mediated ribosomal stalling. This method quantizes forces exerted by translocation machinery, aiding neurodegenerative disease research.

Keywords:
Cotranslational foldingPrion proteinPulling forceXBP1-arrest peptidesemi-permeabilized cells

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