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Updated: Dec 15, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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Altered age-linked regulation of plasma DYRK1A in elderly cognitive complainers (INSIGHT-preAD study) with high brain

Jean M Delabar1,2, Marion Ortner3, Stephanie Simon4

  • 1INSERM U 1127, CNRS UMR 7225 UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et la Moelle épinière, ICM Sorbonne Universités Paris France.

Alzheimer'S & Dementia (New York, N. Y.)
|July 10, 2020
PubMed
Abstract

Insights

Plasma DYRK1A levels may help identify early Alzheimer's disease (AD) risk. Higher DYRK1A in cognitively impaired individuals suggests a blockage of age-related increases, potentially indicating early brain changes and amyloid beta pathology.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Aging Research

Background:

  • Effective Alzheimer's disease (AD) therapies are lacking, partly due to pre-symptomatic pathological changes.
  • Decreased plasma DYRK1A levels have been linked to mild cognitive impairment (MCI) and AD.
  • Aged mice exhibit elevated DYRK1A levels, suggesting an age-related DYRK1A increase.

Purpose of the Study:

  • To investigate DYRK1A levels in plasma of elderly individuals with varying cognitive status and brain amyloid load.
  • To determine if plasma DYRK1A can serve as a biomarker for early detection of amyloid beta pathology in memory complainers.

Main Methods:

  • Assessed DYRK1A levels in plasma from young/aged controls and elderly individuals reporting cognitive complaints.
  • Categorized elderly participants into low (L) and high (H) brain amyloid load groups.
  • Measured clusterin levels for comparison.

Main Results:

  • Human DYRK1A plasma levels increase with age.
  • Elderly individuals with high amyloid load (H group) showed DYRK1A levels similar to young adults, indicating a blocked age-associated increase.
  • Clusterin levels were comparable between L and H groups.

Conclusions:

  • Plasma DYRK1A levels reflect early brain changes associated with cognitive decline.
  • Plasma DYRK1A, unlike clusterin, shows potential as a biomarker for classifying elderly memory complainers at risk for amyloid beta pathology.
Keywords:
Alzheimer's diseaseagingblood markerimmunometric test

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