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IL-2-PE40 is cytotoxic for activated T lymphocytes expressing IL-2 receptors
M Ogata1, H Lorberboum-Galski, D FitzGerald
1Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892.
Journal of Immunology (Baltimore, Md. : 1950)
|December 15, 1988
Abstract:
IL-2-PE40 is a chimeric molecule in which IL-2 is attached to the amino end of modified Pseudomonas exotoxin molecule lacking cell recognition domain. This molecule was extremely toxic for Con A-stimulated spleen cells from mice. Moreover, IL-2-PE40 has suppressive effect against Ag-activated cells; it inhibits the generation of cytotoxic T lymphocyte activity in a MLC. IL-2-PE40 could be a useful agent in IL-2R targeting therapy including immunosuppressive therapy for allograft rejection or some autoimmune diseases.