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Thyroid hormone levels are associated with metabolic components: a cross-sectional study
Ante Punda, Veselin Škrabić, Vesela Torlak
1Tatijana Zemunik, Department of Medical Biology, University of Split School of Medicine,Šoltanska 2, 21000 Split, Croatia, tzemunik@mefst.hr.
Croatian Medical Journal
|July 10, 2020
Summary
Thyroid hormone levels, including TSH, fT3, and fT4, are linked to metabolic syndrome (MetS) components. While thyroid function groups showed no direct MetS association, hormone levels correlate with insulin resistance and cholesterol.
Area of Science:
- Endocrinology
- Metabolic Health
- Population Health
Background:
- Metabolic syndrome (MetS) is a cluster of conditions increasing cardiovascular risk.
- Thyroid dysfunction is increasingly recognized for its potential impact on metabolic parameters.
Purpose of the Study:
- To investigate the relationship between thyroid function and hormone levels with MetS and its individual components.
- To analyze associations in a population without pre-existing thyroid disease or metabolic disorders.
Main Methods:
- Cross-sectional, population-based study of 2183 Croatian adults.
- MetS diagnosis based on National Cholesterol Education Program's Adult Treatment Panel III criteria.
- Analysis of thyroid function groups and specific hormone levels (TSH, fT3, fT4).
Main Results:
- No significant association found between thyroid function groups and MetS prevalence.
- Clinically hypothyroid individuals had higher skinfold measurements (triceps, abdominal).
- Thyroid-stimulating hormone (TSH) positively associated with HOMA-IR and cholesterol; fT3 and fT4 negatively associated.
Conclusions:
- TSH, fT3, and fT4 levels are significant indicators in understanding the association between thyroid function and MetS.
- Hormone levels, rather than broad thyroid function categories, appear more closely linked to specific metabolic risk factors.
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