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B cell activation in patients with active procainamide induced lupus
J Forrester1, J Golbus, D Brede
1University of Michigan, Ann Arbor.
The Journal of Rheumatology
|September 1, 1988
Summary
Procainamide-induced lupus patients show B cell activation, similar to idiopathic lupus. This study found increased IgG synthesis in symptomatic patients, indicating specific immune responses.
Area of Science:
- Immunology
- Rheumatology
- Pharmacology
Background:
- Cellular immune abnormalities are noted in asymptomatic patients on procainamide.
- Previous research has not identified these abnormalities in patients with active procainamide-induced lupus.
Purpose of the Study:
- To investigate T and B cell activation in patients with active procainamide-induced lupus.
- To compare immune activation markers with those found in idiopathic lupus erythematosus.
Main Methods:
- Analysis of T and B cell activation markers in symptomatic procainamide lupus patients.
- Measurement of spontaneous immunoglobulin G (IgG) synthesis.
- Comparison with age-matched healthy controls.
Main Results:
- Symptomatic patients with procainamide lupus exhibited a significant increase in spontaneous IgG synthesis.
- No significant differences were observed in T cells bearing activation markers compared to controls.
- Evidence of B cell activation was demonstrated in these patients.
Conclusions:
- Active procainamide-induced lupus is characterized by B cell activation.
- This B cell activation mirrors findings in idiopathic lupus.
- Procainamide therapy can lead to specific immune dysregulation resembling autoimmune conditions.