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Polymers02:34

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The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Silica gel column chromatography is a technique for separating compounds using a column packed with silica gel as the stationary phase. This method relies on differences in the polarity of compounds. Based on their polarities, compounds move between the stationary phase (silica gel) and the mobile phase (the solvent), forming discrete bands in the column.
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Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
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Core-shell particles having silica cores and pH-responsive poly(vinylpyridine) shells.

Rob Atkin1, Melanie Bradley1, Brian Vincent1

  • 1School of Chemistry, University of Bristol, Cantock's Close, Bristol, UKBS8 1TS. melanie.bradley@bristol.ac.uk.

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|July 11, 2020
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Summary

Researchers developed core-shell particles with pH-responsive polymer shells. These particles, created using seeded growth, show potential for controlled release applications.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Core-shell particles offer unique properties for advanced applications.
  • pH-responsive materials are crucial for tunable drug delivery systems.
  • Existing methods for creating thick polymer shells can be complex.

Purpose of the Study:

  • To develop a novel method for synthesizing core-shell particles with thick, pH-responsive polymer shells.
  • To investigate the influence of surface coverage on shell formation and properties.
  • To explore the potential of these particles in controlled release applications.

Main Methods:

  • Preparation of "raspberry-like" structures using poly(vinylpyridine) (PVP) microgel particles adsorbed onto silica spheres.
  • Seeded growth polymerization of vinylpyridine and divinylbenzene initiated within the PVP sheath.
  • Characterization using optical and electron microscopy to assess shell thickness, continuity, and pH-responsiveness.

Main Results:

  • Successful synthesis of core-shell particles with tunable polymer shell thickness and continuity.
  • Demonstrated pH-responsive swelling and de-swelling behavior of the polymer shell.
  • Shell properties were dependent on the initial surface coverage of PVP particles.

Conclusions:

  • A new, effective method for creating core-shell particles with thick, pH-responsive polymer shells has been established.
  • The developed particles exhibit properties suitable for controlled release applications.
  • Further research into optimizing synthesis parameters and exploring specific delivery applications is warranted.