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Related Concept Videos

Schemas01:42

Schemas

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A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
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Introduction to Structures01:30

Introduction to Structures

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A structure is defined as a system of interconnected members designed to support or transfer forces and successfully withstand the loads acting on them. The internal forces of a structure can be determined by decomposing the structure and analyzing the free-body diagrams of the individual members or of a combination of members. This helps in understanding the structural elements' behavior and ensuring that the structure is stable and can withstand the subjected loads.
There are three main...
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Schemata01:17

Schemata

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A schema is a mental construct that organizes related concepts, allowing the brain to process information efficiently. Upon activation, schemata facilitate assumptions about people or objects.
Two types of schemata are:
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Design Consideration01:22

Design Consideration

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Designing a structure involves a series of considerations, primarily the material's ultimate strength, calculated through tests that measure changes under increased force until the material reaches its breaking point or limit. The ultimate load, where the material breaks, is divided by its original cross-sectional area, resulting in the ultimate normal stress or strength. The ultimate shearing stress is another significant factor taken into account.
The factor of safety is another key...
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Impact of Schemas01:30

Impact of Schemas

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Schemas are cognitive structures that provide a framework for interpreting and organizing social information. They help individuals navigate complex environments by offering expectations about people, events, and behaviors. Schemas influence attention, encoding, and retrieval processes, thereby shaping the entire trajectory of information processing in social contexts.Attention and Cognitive LoadDuring initial attention, schemas function as filters that prioritize schema-consistent information,...
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Frames01:30

Frames

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Frames are essential components of various mechanical and structural systems used daily. These structures are known for their stability and ability to bear heavy loads. A frame is constructed using two-force and multi-force members, interconnected using pin joints. In contrast, trusses are made entirely of two-force members.
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A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
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Thoughts on Scaffolds.

Suwan N Jayasinghe1

  • 1BioPhysics Group, UCL Centre for Stem Cells and Regenerative Medicine, UCL Department of Mechanical Engineering and UCL Institute of Healthcare Engineering, University College London, Torrington Place, London, WC1E 7JE, United Kingdom.

Advanced Biosystems
|July 11, 2020
PubMed
Summary
This summary is machine-generated.

New scaffolding technologies overcome limitations in tissue engineering, enabling the creation of functional three-dimensional tissues. These versatile platform biotechnologies promise significant advancements for regenerative medicine and biomaterials.

Keywords:
bio-electrosprayingbiological modelscell electrospinningin vitro and in vivo studiesscaffoldsthree-dimensional tissues

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Area of Science:

  • Regenerative Biology and Medicine
  • Biomaterials Engineering
  • Tissue Engineering

Background:

  • Scaffolds are crucial for engineering functional tissues, but current methods face limitations.
  • Existing approaches struggle with cell infiltration, cost, and time for creating native-like tissues.
  • Previous scaffolds have not achieved widespread biomedical or clinical utility.

Purpose of the Study:

  • To highlight recent advancements in scaffolding technologies.
  • To address the limitations of traditional tissue engineering scaffolds.
  • To introduce novel platform biotechnologies for creating three-dimensional living tissues.

Main Methods:

  • Development of new scaffolding technologies since 2005.
  • Utilizing biopolymers and advanced materials with multiple cell types.
  • Integration of cells and materials for simultaneous three-dimensional reconstruct formation.

Main Results:

  • New technologies enable direct handling of large quantities of multiple cell types.
  • Simultaneous formation of three-dimensional living reconstructs mimicking native tissues.
  • Overcoming previous roadblocks like poor cell infiltration and lengthy generation times.

Conclusions:

  • Recent scaffolding innovations offer versatile solutions for tissue engineering.
  • These platform biotechnologies have significant potential for regenerative medicine.
  • The new technologies overcome critical limitations, paving the way for clinical applications.