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Published on: August 6, 2021
Association of MMP2-1306C/T Polymorphism with Ischemic Retinal Vein Occlusion
Aikaterini Christodoulou1, Eleni Bagli1, Maria Gazouli2
1University Eye Clinic of Ioannina, Greece.
Purpose:
To investigate the possible association of the matrix metalloproteinase 2 (MMP2)-1306C/T polymorphism with the risk of ischemic retinal vein occlusion (iRVO).
Methods:
A total of 69 patients with RVO were enrolled in this study (43 with non-iRVO and 26 with iRVO). All subjects were screened for hypertension, diabetes mellitus, hyperlipidemia, history of stroke, anticoagulant medication, smoking status and glaucoma. The genotyping of MMP2-1306C/T polymorphism was performed using PCR-RFLP-based methods.
Results:
MMP2-1306C/T T allele carriers (CT+TT) were statistically significant associated with a higher risk of iRVO compared to CC genotype in the overall RVO group (odds ratio = 3.91, p = 0.015, 95% confidence interval:1.30-11.79). Analysis, following stratification by age revealed that T allele carriers had a statistically significant increased risk of iRVO compared to C allele carriers only in RVO patients <75 years old.
Conclusion:
Our results demonstrated that MMP2-1306C/T polymorphism is a likely predisposing factor for iRVO in patients <75 years old. This is the first study attempting association of a gene polymorphism with the prevalence of iRVO.
Insights
The MMP2-1306C/T gene polymorphism is linked to an increased risk of ischemic retinal vein occlusion (iRVO) in patients under 75 years old. This finding suggests a potential genetic predisposition for iRVO.
Area of Science:
- Ophthalmology
- Genetics
- Medical Research
Background:
- Ischemic retinal vein occlusion (iRVO) is a significant cause of vision loss.
- Genetic factors may play a role in the development of iRVO.
- The matrix metalloproteinase 2 (MMP2) gene is a potential candidate for investigation.
Purpose of the Study:
- To investigate the association between the matrix metalloproteinase 2 (MMP2)-1306C/T polymorphism and the risk of iRVO.
- To determine if MMP2-1306C/T polymorphism is a predisposing factor for iRVO.
Main Methods:
- Genotyping of the MMP2-1306C/T polymorphism using PCR-RFLP.
- Study included 69 patients with retinal vein occlusion (RVO), categorized into iRVO and non-iRVO groups.
- Screening for traditional risk factors including hypertension, diabetes, hyperlipidemia, and smoking.
Main Results:
- MMP2-1306C/T T allele carriers (CT+TT) showed a significantly higher risk of iRVO (OR=3.91, p=0.015).
- This association was particularly significant in RVO patients younger than 75 years old.
- No significant association was found in RVO patients aged 75 years or older.
Conclusions:
- The MMP2-1306C/T polymorphism is a likely predisposing factor for iRVO in patients under 75 years old.
- This study is the first to explore the association between a specific gene polymorphism and iRVO prevalence.
- Further research is warranted to elucidate the role of MMP2 in iRVO pathogenesis.
